Table 2. MICs of MGB-BP-3 against Gram-Negative ESKAPE Pathogens in the Presence and Absence of PMBN (30 μg/mL) and PAβN (25 μg/mL in 0.04 mM MgSO4)a.
| MGB-BP-3 (μM) |
|||||
|---|---|---|---|---|---|
| organism | strain | +PMBN | +PaβN | CIP (μg/mL) | |
| K. pneumoniae | NCTC 13368 | >100 | >100 | >100 | 0.5 |
| K. pneumoniae | M6 | >100 | 3.13 | 1.56 | ≤0.125 |
| A. baumannii | AYE | >100 | 3.13 | 6.25 | 64 |
| A. baumannii | ATCC 17978 | >100 | 0.78–3.13 | 0.78–3.13 | 0.5 |
| P. aeruginosa | PA01 | >100 | 0.39–3.13 | >100 | 0.5 |
| P. aeruginosa | NCTC 13437 | >100 | >100 | >100 | 64 |
| E. coli | NCTC 12923 | >100 | 0.78 | 0.78 | ≤0.125 |
a
Ciprofloxacin (CIP) was included as a control antibiotic.