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. 2022 Nov 7;8(12):2396–2404. doi: 10.1021/acsinfecdis.2c00307

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© 2022 The Authors. Published by American Chemical Society

Permits the broadest form of re-use including for commercial purposes, provided that author attribution and integrity are maintained (https://creativecommons.org/licenses/by/4.0/).

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Analysis of rifampicin potentiation by enantiomeric pairs PmxB₄/ent-PmxB₄ and PMBN/ent-PMBN against polymyxin-sensitive and polymyxin-resistant bacteria. (A) Checkerboard assays to assess the synergy of rifampicin with PmxB4/ent-PmxB4 and PMBN/ent-PMBN against polymyxin-sensitive E. coli ATCC 25922. (B) Checkerboard assays to assess the synergy of rifampicin with PmxB4/ent-PmxB4 and PMBN/ent-PMBN against polymyxin-resistant (mcr-1 positive) E. coli. Color corresponds to growth (as read by OD₆₀₀) after incubation and with intensity proportional to the observed OD₆₀₀ value. White areas indicate no growth. Bounded box indicates the combination of concentrations that gives the lowest FIC index value. Values used for FICI calculations are shown in Table S4.