Table 4. Potencies (pEC50) and Efficacies (Emax) of CB1 Internalization by Cannabinoid Ligands over 60 mina.
| ligand | pEC50 | Emax (min–1, span) |
|---|---|---|
| THC | 7.66 ± 0.08 | 0.0075 ± 0.0010 |
| THC + 100 nM ZCZ011 | 7.76 ± 0.13 | 0.0148 ± 0.0004* |
| THC + 1 μM ZCZ011 | 7.89 ± 0.03 | 0.0260 ± 0.0018* |
a
Data is presented as mean ± SEM of five independent biological replicates, with Emax expressed as the span of the curve. Statistical tests (comparing THC alone to all other conditions) were performed in GraphPad Prism using a repeated measures one-way ANOVA with Dunnett’s posthoc tests; p values indicated as * < 0.05.