Skip to main content
. 2022 Nov 28;16(3 Suppl 1):101–120. doi: 10.1590/1980-5764-DN-2022-S107PT

Table 2. Consensus-based recommendation for the use of psychotropic medication in specific behavior and psychological symptoms of dementia (BPSD) associated with severe Alzheimer’s dementia.

BPSD Suggested dose range* Side effects
Agitation or aggression Citalopram** 10-20mg/day, single dose nausea, diarrhea, headache, increased risk of falls
Sertraline 50-100mg/day, single dose
Trazodone*** 25-100mg/day, single/partial doses
Risperidone 0.25-1mg/day, single dose extrapyramidal side effects, weight gain, metabolic abnormalities, hyperprolactinemia
Psychosis Risperidone 1-3mg/day, single dose extrapyramidal side effects, weight gain, metabolic abnormalities, hyperprolactinemia
Quetiapine 100-200mg/day, single/ partial doses drowsiness, weight gain, metabolic abnormalities
Aripiprazole 10-30mg/day, single dose nausea, weight gain, headache, somnolence, akathisia

*Doses are recommended based on clinical trials and personal experience, considering the pharmacological properties of these agents; **May consider escitalopram due to its greater safety and better cognitive profile. It is also more commonly prescribed in Brazil than citalopram; ***Although it has less evidence than the other agents, this drug shows a good balance between safety and effectiveness in clinical practice. Extended-release formulation is better during the day to avoid somnolence.