Table 2. Consensus-based recommendation for the use of psychotropic medication in specific behavior and psychological symptoms of dementia (BPSD) associated with severe Alzheimer’s dementia.
BPSD | Suggested dose range* | Side effects | |
---|---|---|---|
Agitation or aggression | Citalopram** | 10-20mg/day, single dose | nausea, diarrhea, headache, increased risk of falls |
Sertraline | 50-100mg/day, single dose | ||
Trazodone*** | 25-100mg/day, single/partial doses | ||
Risperidone | 0.25-1mg/day, single dose | extrapyramidal side effects, weight gain, metabolic abnormalities, hyperprolactinemia | |
Psychosis | Risperidone | 1-3mg/day, single dose | extrapyramidal side effects, weight gain, metabolic abnormalities, hyperprolactinemia |
Quetiapine | 100-200mg/day, single/ partial doses | drowsiness, weight gain, metabolic abnormalities | |
Aripiprazole | 10-30mg/day, single dose | nausea, weight gain, headache, somnolence, akathisia |
*Doses are recommended based on clinical trials and personal experience, considering the pharmacological properties of these agents; **May consider escitalopram due to its greater safety and better cognitive profile. It is also more commonly prescribed in Brazil than citalopram; ***Although it has less evidence than the other agents, this drug shows a good balance between safety and effectiveness in clinical practice. Extended-release formulation is better during the day to avoid somnolence.