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Efficient DNA repair pathways due to high activity of SIRT6. Long‐lived rodents including NMRs have higher SIRT6 activity than short‐lived rodents, which may contribute to the increased activity of PARP1. As a result, poly‐ADP‐ribosylation by PARP1, which is an important initial response for the initiation of DSB repair and base excision repair, may be activated.
