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. 2022 Oct 12;113(12):4120–4134. doi: 10.1111/cas.15571

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© 2022 The Authors. Cancer Science published by John Wiley & Sons Australia, Ltd on behalf of Japanese Cancer Association.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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MicroRNA (miR)‐370‐3p attenuated interleukin‐8 (IL‐8)‐induced liver cancer cell metastasis. (A) IL‐8‐induced expression of Snail and Twist1 was attenuated when miR‐370‐3p mimic molecules were transfected into cells prior to IL‐8 treatment. (B) Overexpression of miR‐370‐3p in Huh‐7 and HepG2 cells rescued the promotion of migration and invasion induced by IL‐8. (C) miR‐370‐3p‐treated mice showed fewer liver metastatic nodules after IL‐8 intraperitoneal injection. Immunohistochemical analysis of tumor tissue sections showed that expression of E‐cadherin increased, whereas Snail, Twist1, and vimentin decreased in Huh‐7^{miR‐370‐3pmimic} mice. **p < 0.01, ***p < 0.001, ****p < 0.0001.