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. 2022 Oct 12;113(12):4120–4134. doi: 10.1111/cas.15571

FIGURE 7.

FIGURE 7

Interleukin‐8 (IL‐8) and microRNA (miR)‐370‐3p levels correlate with hepatocellular carcinoma (HCC) patient prognosis. (A) Serum IL‐8 levels of HCC patients before and after transcatheter arterial chemoembolization (TACE) were tested by ELISA. (B) IL‐8 concentration in the culture supernatant of HCC cells treated with doxorubicin, oxaliplatin, and sorafenib. (C) miR‐370‐3p levels in seven different genetic HCC cell lines were significantly lower than nontransformed hepatic cell line LO2. (D) miR‐370‐3p levels were lower in cancer in both The Cancer Genome Atlas (TCGA) database and clinical samples. (E) Spearman's correlation analysis indicated that miR‐370‐3p expression was inversely correlated with IL‐8 mRNA levels in HCC patients. (F) Comparison of progression‐free survival and overall survival between different expression levels of miR‐370‐3p and IL‐8 in HCC patients. Actuarial probabilities were calculated using the Kaplan–Meier method and compared using the log–rank test. HCC patients with miR‐370‐3phigh and IL‐8low showed much better PFS and OS. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001. ns, not significant.