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(A) Structure of DSPE‐PGlu(DET‐Car)30. (B) Schematic illustration of siRNA‐encapsulated PGlu(DET‐Car)30 LNPs. (C) How PGlu(DET‐Car)30 LNPs facilitate tumor accumulation through pH switchable properties. (D) TEM image of LNP. LNP would switch to a positive charge in response to a tumor acidic environment via protonated amino groups of polymers to enhance tumor accumulation. Cationic LNP would improve the interaction with anionic cell membrane for effective siRNA delivery
