FIGURE 7.

Knocking down SAR1A suppresses the in vivo metastasis of osteosarcoma cells. (A) Gross and H&E‐stained images of metastatic nodules from nude mice in the normal control (shNC) and shSAR1A‐2 groups. (B) Changes in bodyweight following in situ tibial 143B cell injection in mice. (C) Lung metastasis numbers in the shSAR1A‐2 and shNC groups. (D) Metastatic pulmonary nodules in shNC and sh‐SAR1A‐2 group mice. (E, F) Active‐RhoA, Non‐p‐YAP, and CTGF levels in primary tumors were measured by western blotting. Analyses were repeated three times. * p <0.05, ** p <0.01 (mean ± SD).