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. Author manuscript; available in PMC: 2022 Dec 13.
Published in final edited form as: Autoimmun Rev. 2021 Sep 10;20(11):102942. doi: 10.1016/j.autrev.2021.102942

Fig. 3.

Fig. 3.

MARCKS and PIP2 colocalize in the nucleus indicating that the MARCKS effector domain is pivotal for regulation of PIP2 traffic to the nucleus and for downstream gene expression. The PI3K-AKT signaling and PIP2 mediated actin skeleton pathways of MARCK are illustrated, along with the positive feedback loop of PKC-MARCKS-PIP2-PLCĪ³-DAG.