Table 3.
Causal effects of gut microbiota on longevity-related traits estimated by MR analysis
| MR | Heterogeneity | Pleiotropy | ||||||
|---|---|---|---|---|---|---|---|---|
| Exposure | Outcome | Method | NSNP | b | Se | P | P | P |
| G_Collinsella_HB | Parental longevity (father's age at death) | MR Egger | 13 | 8.38×10-4 | 1.42×10-3 | 5.66×10-1 | 4.30×10-1 | 7.57×10-1 |
| Weighted median | 13 | 1.79×10-3 | 8.48×10-4 | 3.52×10-2 | ||||
| Inverse variance weighted | 13 | 1.23×10-3 | 6.86×10-4 | 7.29×10-2 | 5.07×10-1 | |||
| Simple mode | 13 | -5.42×10-5 | 2.06×10-3 | 9.79×10-1 | ||||
| Weighted mode | 13 | 1.52×10-3 | 7.95×10-4 | 8.00×10-2 | ||||
| G_Veillonella_HB | Parental longevity (mother's attained age) | Wald ratio | 1 | 7.27×10-3 | 2.96×10-3 | 1.43×10-2 | ||
| Lifespan | Wald ratio | 1 | -2.43×10-2 | 1.00×10-2 | 1.52×10-2 | |||
| Healthspan | Wald ratio | 1 | -2.59×10-2 | 1.17×10-2 | 2.67×10-2 | |||
| Parental longevity (combined parental attained age, Martingale residuals) | Wald ratio | 1 | 6.36×10-3 | 3.03×10-3 | 3.62×10-2 | |||
G Genus, RNT Rank-normal transformation, HB Hurdle binary; b means the estimated causal effect