Table 4.
Causal effects of longevity-related traits on gut microbiota estimated by MR analysis
| MR | Heterogeneity | Pleiotropy | ||||||
|---|---|---|---|---|---|---|---|---|
| Exposure | Outcome | Method | NSNP | b | Se | P | P | P |
| Longevity | G_Collinsella_HB | MR Egger | 42 | -0.20 | 0.16 | 2.05×10-1 | 9.99×10-1 | 4.60×10-1 |
| Weighted median | 42 | -0.31 | 0.09 | 1.05×10-3 | ||||
| Inverse variance weighted | 42 | -0.31 | 0.07 | 1.43×10-5 | 9.99×10-1 | |||
| Simple mode | 42 | -0.31 | 0.16 | 5.42×10-2 | ||||
| Weighted mode | 42 | -0.28 | 0.14 | 4.41×10-2 | ||||
| Healthspan | G_Collinsella_HB | MR Egger | 331 | -1.19 | 0.74 | 1.07×10-1 | 1.00 | 1.08×10-1 |
| Weighted median | 331 | -0.09 | 0.24 | 7.18×10-1 | ||||
| Inverse variance weighted | 331 | -0.04 | 0.18 | 8.39×10-1 | 1.00 | |||
| Simple mode | 331 | 1.31 | 0.76 | 8.61×10-2 | ||||
| Weighted mode | 331 | -1.40 | 0.69 | 4.40×10-2 | ||||
| Longevity | G_Sporobacter_HB | MR Egger | 42 | 0.84 | 0.15 | 2.05×10-6 | 9.85×10-1 | 3.22×10-1 |
| Weighted median | 42 | 0.66 | 0.10 | 7.24×10-12 | ||||
| Inverse variance weighted | 42 | 0.70 | 0.07 | 4.21×10-25 | 9.84×10-1 | |||
| Simple mode | 42 | 0.61 | 0.16 | 6.28×10-4 | ||||
| Weighted mode | 42 | 0.68 | 0.14 | 1.79×10-5 | ||||
| Parental longevity (combined parental age at death) | G_Sporobacter_HB | MR Egger | 6 | 15.08 | 5.08 | 4.13×10-2 | 5.39×10-1 | 5.93×10-2 |
| Weighted median | 6 | 1.68 | 2.84 | 5.55×10-1 | ||||
| Inverse variance weighted | 6 | 2.63 | 2.50 | 2.92×10-1 | 7.72×10-2 | |||
| Simple mode | 6 | -1.00 | 5.39 | 8.61×10-1 | ||||
| Weighted mode | 6 | -1.78 | 5.10 | 7.41×10-1 | ||||
| Parental longevity (combined parental attained age, Martingale residuals) | G_Sporobacter_HB | MR Egger | 10 | -7.63 | 3.11 | 3.96×10-2 | 8.54×10-1 | 6.22×10-2 |
| Weighted median | 10 | -1.00 | 2.18 | 6.46×10-1 | ||||
| Inverse variance weighted | 10 | -1.78 | 1.54 | 2.47×10-1 | 4.63×10-1 | |||
| Simple mode | 10 | 0.98 | 4.24 | 8.22×10-1 | ||||
| Weighted mode | 10 | -6.41 | 2.49 | 3.01×10-2 | ||||
| Parental longevity (both parents in top 10%) | G_Sporobacter_HB | MR Egger | 6 | 14.23 | 5.22 | 5.26×10-2 | 7.47×10-1 | 9.08×10-2 |
| Weighted median | 6 | 5.05 | 3.35 | 1.32×10-1 | ||||
| Inverse variance weighted | 6 | 4.17 | 3.02 | 1.68×10-1 | 2.31×10-1 | |||
| Simple mode | 6 | 2.04 | 7.42 | 7.94×10-1 | ||||
| Weighted mode | 6 | 8.54 | 3.30 | 4.91×10-2 | ||||
| Parental longevity (95 years and older) | G_Sporobacter_HB | Wald ratio | 1 | 51.75 | 25.07 | 3.90×10-2 | ||
| Parental longevity (mother's age at death) | G_Sporobacter_HB | Wald ratio | 1 | 11.00 | 4.04 | 6.41×10-3 | ||
G Genus, RNT Rank-normal transformation, HB Hurdle binary; b means the estimated causal effect