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. 2022 Dec 13;28:155. doi: 10.1186/s10020-022-00526-0

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — Bioinformatics analysis to screen the signaling pathways related to hUCMSCs@Ex-4 in the treatment of T1DM and changes in intestinal microflora. A Venn diagram of the exenatide-related genes and T1DM target genes determined using GeneCards. B The drug-target regulatory network. C GO enrichment analysis of 26 target genes. D, KEGG enrichment analysis of the 26 target genes. E Venn diagram of T1DM-related intestinal microflora predicted by the GMrepo, HMDAD, gutMEGA, and gutMDisorder databases. F Fecal intestinal microflora specie cladogram of T1DM mice treated with hUCMSCs@Ex-4 (red) and T1DM mice (green). G Differential fecal intestinal microflora species between T1DM mice treated with hUCMSCs@Ex-4 (red) and T1DM mice (green)