Fig. 1.

Schematics of the study design and flowchart of analyses performed in this study. A Instrumental variables were selected from multi-tissue pQTL datasets and used for performing Mendelian randomization with 211 disease-related phenotypes. B In summary, eight steps were implemented in this study: step 1 as outcome selection; step 2 as genetics instrumental variables selection; step 3 as validation of genetic instrumental variables; step 4 as MR and colocalization analyses with two workflows—(4a) cis-only instrumental variables passing study-wide significance and (4b) cis- and trans-instrumental variables passing genome-wide significance; step 5 as combinations of workflows of protein-phenotype associations within each tissue; step 6 as cross-tissue comparisons of the same protein-phenotype associations; step 7 as enrichment with druggable genome; and step 8 as drug repositioning