Table 2. Histologic findings in published case series.
| Markowitz et al. (2002) [3] | Li and Verani (2008) [9] | Wu et al. (2013) [7] | Salvatore et al. (2015) [8]* | |
|---|---|---|---|---|
| Light microscopy | ||||
| Global glomerulosclerosis, % | 85 | 24 | ||
| Nodular mesangial matrix, % | 100 | 100 | 100 | 100 |
| Thickening of glomerular basement membrane, % | 100 | 100 | 100 | |
| Glomerulomegaly, % | 100 | 100 | 100 | 100 |
| Interstitial fibrosis and/or tubular atrophy, % | 100 | 100 | 100 | 100 |
| Mild (< 25%) | 52 | 20 | 20 | Mean 48 (35 – 60) |
| Moderate (25 – 50%) | 61 | 53 | 30 | |
| Severe (> 50%) | 22 | 27 | 50 | |
| Arteriosclerosis, % | 100 | 100 | 100 | |
| Mild | 17 | 0 | 0 | |
| Moderate | 61 | 73 | 25 | |
| Severe | 28 | 27 | 75 | |
| Hyalinosis and arteriolosclerosis, % | 100 | 100 | 100 | |
| Mild | 4 | 0 | 20 | |
| Moderate | 57 | 53 | 70 | |
| Severe | 39 | 47 | 10 | |
| Immunofluorescence | ||||
| Immune deposits / reactivity, % | 0 | 0 | 0 | 0 |
| Non-specific IgM/C3, % | 70 | 80 | Infrequent and unspecific patterns, IgG, IgM, C3, and albumin | |
| Linear staining of GBM and TBM for albumin and IgG, % | 44 IgG, 48 albumin | 53 | ||
| Electron microscopy | ||||
| Dense deposits, % | 0 | 0 | 0 | |
| Fibrils, % | 0 | 0 | ||
| GBM thickening, % | 100 | 100 | 100 | 100 |
| Foot process effacement, % | 46 (fusion) | 100 | 100 | 100 |
| Diffuse, % | 67 | 65 | ||
| Segmental, % | 33 | 35 (focal) | ||
*Six patients were excluded for the absence of nodular glomerulosclerosis pattern. GBM = glomerular basement membrane; TBM = tubular basement membrane.