Table 3. Non-diabetic metabolic nodular glomerulosclerosis summary.

Non-diabetic metabolic nodular glomerulosclerosis – key concepts
Clinical presentation	Male > female Advanced age (+/– 60 years old) Late diagnosis (Advanced kidney dysfunction at diagnosis) Proteinuria (frequently nephrotic) +/- microhematuria
Comorbidities	Hypertension Smoking Obesity Hypercholesterolemia
Biopsy	Light microscopy: Nodular glomerulosclerosis, glomerulomegaly arteriosclerosis, hyalinosis, tubulointerstitial fibrosis Immunofluorescence: Negative/unspecific Electron microscopy: Thickening of GBM, podocytes foot process effacement no dense deposits or fibrils, thickening of GBM, podocytes foot process effacement
Treatment	Risk factors control (smoke cessation, hypertension control) Maximum tolerated dose of ACEi/ARA
Prognosis	Poor, 30% reach ESRD