TABLE 1.
Antibacterial, antifungal, and cytotoxic activities (in human cancer cell lines) of compounds 1−8a
| Compound | Antibacterial (IC90, μg/mL) |
Antifungal (IC50, μg/mL) |
Cytotoxic (IC50, μg/mL) |
||||
|---|---|---|---|---|---|---|---|
| S. aureus | K. aerogenes | C. albicans | A. fumigatus | A549 | MIA PaCa-2 | PANC-1 | |
| 1 | >100 | >100 | >100 | >100 | >100 | >100 | >100 |
| 2 | >100 | >100 | >100 | >100 | >100 | >100 | >100 |
| 3 | 71.4 | >100 | >100 | >100 | 3.0 | 0.9 | 5.5 |
| 4 | >100 | >100 | >100 | >100 | 5.3 | 1.1 | 5.3 |
| 5 | 1.8 | >100 | >100 | >100 | 2.8 | 1.2 | 7.8 |
| 6 | >100 | >100 | 18.8 | >100 | 50.8 | 49.3 | 57.4 |
| 7 | >100 | >100 | >100 | >100 | >100 | >100 | >100 |
| 8 | 6.7 | >100 | >100 | >100 | 50.2 | 46.4 | 53.0 |
| Gentamicin | 0.15 | 0.10 | / | / | / | / | / |
| Amphotericin B | / | / | 0.28 | 0.12 | / | / | / |
| Puromycin | / | / | / | / | 1.04 | 0.68 | 1.13 |
a
/, denotes undetected bioactivity.