Table 2.

Performance of the new 10-year risk score in the 30% testing dataset

Association	HR per quintile of risk	95% CI	P value
New 10-year risk score	1.338	1.152–1.553	<0.001
Discrimination	Harrell’s C-index	95% CI
New 10-year risk score	0.663	0.629–0.698
Calibration	SIR	95% CI	P value*
Overall	1.000	0.874–1.145	1.0
Quintile 1 (median = 0.16%)	0.592	0.203–0.982	0.1
Quintile 2 (median = 0.26%)	0.843	0.468–1.218	0.4
Quintile 3 (median = 0.35%)	0.920	0.589–1.250	0.6
Quintile 4 (median = 0.44%)	1.075	0.759–1.391	0.6
Quintile 5 (median = 0.60%)	1.133	0.888–1.379	0.3

CI, confidence interval; HR, hazard ratio; SIR, standardised incidence ratio. The SIR is the observed number of ovarian cancer cases divided by the number expected by the 10-year risk prediction score.

^*P value for test that SIR = 1.