Table 3.
Comparison of associated factors between pneumococcal vaccinated group and non-vaccinated group in patients with chronic obstructive pulmonary disease.
| Characteristics | Pneumococcal vaccination |
P-value | |
|---|---|---|---|
| Vaccinated (n = 59) | Unvaccinated (n = 75) | ||
| Age, years | 77.00 ± 9.35 | 74.13 ± 8.00 | .058 |
| Male | 56 (94.9) | 66 (88.0) | .164 |
| Ex-smoking | 54 (91.5) | 68 (90.7) | .863 |
| Smoking, pack-years | 27.82 ± 19.42 | 26.84 ± 20.72 | .781 |
| Comorbidity | |||
| Hypertension | 40 (67.8) | 44 (58.7) | .278 |
| Diabetes | 18 (30.5) | 16 (21.3) | .226 |
| Heart disease | 23 (39.0) | 11 (14.7) | .001 |
| Renal disease | 8 (13.6) | 4 (5.3) | .098 |
| Lung disease | 4 (6.8) | 0 (0) | .035 |
| Influenza vaccination | 59 (100.0) | 43 (57.3) | <.001 |
| Physician | |||
| Pulmonologist | 54 (91.5) | 29 (38.7) | <.001 |
| Internist | 5 (8.5) | 46 (61.3) | |
| Exacerbation, events | 1.51 ± 2.82 | 0.96 ± 2.66 | .251 |
| Hospitalization, events | 0.76 ± 1.72 | 0.56 ± 1.77 | .506 |
| Spirometry data | |||
| Post-BD FVC, L | 2.35 ± 0.74 | 2.50 ± 0.69 | .076 |
| Post-BD FVC, % predicted | 78.41 ± 22.16 | 86.34 ± 18.87 | .037 |
| Post-BD FEV1, L | 1.30 ± 0.48 | 1.52 ± 0.55 | .024 |
| Post-BD FEV1, %predicted | 60.89 ± 28.71 | 68.57 ± 21.41 | .096 |
| FEV1 change after BD, % | 8.66 ± 12.69 | 5.92 ± 8.56 | .142 |
| Pre-BD FEV1/FVC, % | 54.22 ± 12.96 | 59.00 ± 12.22 | .037 |
| Post-BD FEV1/FVC, % | 54.87 ± 12.08 | 58.27 ± 1.53 | .148 |
| Functional performance | |||
| mMRC, points | 2.08 ± 1.12 | 1.67 ± 1.25 | .046 |
| CAT score, points | 10.32 ± 6.14 | 8.87 ± 7.52 | .231 |
Data shown as mean ± SD or n (%).
BD = bronchodilator, CAT = COPD assessment test, FEV1 = forced expiratory volume in 1 second, FVC = forced vital capacity, L = liters, mMRC=modified Medical Research Council, PCV13 = 13-valent pneumococcal conjugate vaccine, PPSV23 = 23-valent pneumococcal polysaccharide vaccine.