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. 2022 Dec 13:1–15. Online ahead of print. doi: 10.1007/s13399-022-03645-0

Table 5.

ANOVA results of regression models from mixture design for solvent optimization of MICs of S. aureus, S. enterica, and E. coli

Source DF Seq SS Adj SS Adj MS F value p value
S. aureus
Regression 6 2.925 2.9256 0.581 8.11 0.047
Linear 2 1.866 2.062 1.031 16.70 0.016
Quadratic 3 1.038 0.0712 0.346 4.00 0.071
X1 × X2 1 0.876 0.638 0.881 10.38 0.053
X1 × X3 1 0.16147 0.095 0.161 2.80 0.066
X2 × X3 1 0.00034 0.00176 0.00034 2.01 0.051
Special cubic 1 0.02085 0.02085 0.02085 4.18 0.043
X1 × X2 × X3 1 0.02085 0.02085 0.02085 4.18 0.043
Residual error 3 0.35564 0.35564 0.11855
Total 9 3.281
S. enterica
Regression 6 0.479 0.479 0.08 2.33 0.042
Linear 2 0.304 0.263 0.131 2.54 0.031
Quadratic 3 0.066 0.088 0.030 2.12 0.072
X1 × X2 1 0.056 0.006 0.006 4.03 0.058
X1 × X3 1 0.005 0.039 0.039 4.16 0.061
X2 × X3 1 0.005 0.039 0.039 5.16 0.084
Special cubic 1 0.109 0.109 0.109 6.45 0.042
X1 × X2 × X3 1 0.109 0.109 0.109 6.45 0.042
Residual error 3 0.732 0.732 0.244
Total 9 1.212
E. coli
Regression 6 0.156 0.156 0.026 2.94 0.013
Linear 2 0.057 0.057 0.028 4.13 0.045
Quadratic 3 0.093 0.087 0.029 4.16 0.079
X1 × X2 1 0.015 0.021 0.021 3.61 0.055
X1 × X3 1 0.066 0.071 0.072 12.34 0.078
X2 × X3 1 0.011 0.016 0.016 2.20 0.094
Special cubic 1 0.006 0.006 0.006 2.44 0.035
X1 × X2 × X3 1 0.006 0.006 0.006 2.44 0.035
Residual error 3 0.040 0.04 0.013
Total 9 0.197