TABLE 1.

Sporozoite neutralization by individual αGP25-200 and αP23 MAbs

MAb	Antigen specificity	ELISA OD, mean ± SD (A405)		% Reduction in infectiona	P
		Test MAb	Isotype control MAb
3H2	GP25-200	1.15 ± 0.10	1.25 ± 0.05	8	<0.05
1B3	GP25-200	0.73 ± 0.03	1.26 ± 0.07	42	<0.0001
1C5	GP25-200	0.57 ± 0.06	0.81 ± 0.09	30	<0.001
1G2	GP25-200	0.81 ± 0.14	1.04 ± 0.16	22	<0.001
2F6	GP25-200	0.77 ± 0.04	0.93 ± 0.06	17	<0.001
3D9	GP25-200	0.45 ± 0.03	0.92 ± 0.08	51	<0.0001
3D11	GP25-200	0.57 ± 0.19	0.77 ± 0.08	26	<0.01
3E8	GP25-200	0.39 ± 0.02	0.71 ± 0.03	45	<0.0001
3F7	GP25-200	0.56 ± 0.19	0.84 ± 0.07	33	<0.001
4D10	GP25-200	0.76 ± 0.07	0.84 ± 0.06	10	<0.05
4E11	GP25-200	0.69 ± 0.05	1.04 ± 0.07	34	<0.0001
4F6	GP25-200	1.09 ± 0.03	1.19 ± 0.07	8	<0.005
4H7	GP25-200	1.15 ± 0.10	1.28 ± 0.11	10	<0.01
4H9	GP25-200	0.61 ± 0.06	0.93 ± 0.08	34	<0.0001
1A9	P23	0.79 ± 0.06	0.87 ± 0.07	9	<0.025
2G6	P23	0.72 ± 0.05	1.26 ± 0.07	43	<0.0001
3C10	P23	0.68 ± 0.03	0.84 ± 0.06	19	<0.0001
3D1	P23	0.61 ± 0.05	0.70 ± 0.04	13	<0.0025
4C11	P23	0.81 ± 0.06	0.97 ± 0.03	16	<0.0025
4E4	P23	0.94 ± 0.08	1.29 ± 0.14	27	<0.0025
5B9	P23	0.68 ± 0.04	0.78 ± 0.06	13	<0.001

^a[(Isotype control MAb OD − test MAb OD) ÷ isotype control MAb OD] × 100.