TABLE 4.

Recognition of distinct epitopes and lack of binding inhibition by lead formulation MAbs

MAb-1	Antigen specificity	Epitope compositiona	Binding of biotinylated MAb-2 (A405)b
			3E2	1E10	3H2
3E2	CSL	C	0.08 ± 0.01	0.96 ± 0.03	0.63 ± 0.03
3H2	GP25-200	C	0.95 ± 0.11	1.06 ± 0.09	0.21 ± 0.02
1E10	P23	P	0.96 ± 0.06	0.31 ± 0.08	0.94 ± 0.05
C4A1	GP25-200	C	0.99 ± 0.07	0.96 ± 0.06	0.90 ± 0.10
C6B6	P23	P	1.05 ± 0.06	0.62 ± 0.03	1.06 ± 0.10
7D10	P23	P	0.96 ± 0.06	0.43 ± 0.02	1.01 ± 0.05
IgM isotype control			1.04 ± 0.12		1.01 ± 0.02
IgG1 isotype control				1.13 ± 0.14

^aP, peptide; C, carbohydrate or carbohydrate-dependent (based on susceptibility to periodate and proteinase K). 

^bMeans and standard deviations from six replicates.