Fig. 1.

Structural similarity between the protein structure queries. The TM-score (in the (0, 1] range) measures the topological similarity between two protein structures: the higher the TM-score, the more similar the two structures. Scores below 0.17 correspond to unrelated proteins, while those above 0.5 usually indicate two structures having the same fold [15]. The corresponding RMSD values are presented in Fig. B.11.