Figure 8. Enrichment of a nonsynonymous mutation (L260F) in the gene encoding nsp6 in ORF1a of SARS-CoV-2 in oral swabs and lung tissue samples of 5 experimentally challenged mink.

Deep sequencing of SARS-CoV-2-positive samples show rapid enrichment for L260F in nsp6 in lung tissue samples but not the oral swabs for 5 of 10 experimentally inoculated mink with SARS-CoV-2 genomic material detected in the lungs. Oral swab samples indicated by blue and lung tissue samples indicated by red, the line indicates group mean. Allele frequency for the L260F mutation is plotted on the y axis.