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. 2022 Nov 22;7(22):e164944. doi: 10.1172/jci.insight.164944

Figure 4. Analysis of epithelial transcriptome by single-cell RNA-Seq.

Figure 4

(A) Global representation of gene expression in epithelia kept under control conditions (left) or treated with IL-17/TNF-α (right). Each dot represents a single cell, whose position in the 2D map reports the transcriptional similarity with respect to the neighbor cells. The different colors and numbers correspond to cells clusters with similar transcriptome. (B) Two-dimensional maps showing the expression of indicated genes within the epithelial cell population. MUC5B, SLC26A4, ATP12A, ADRB2, SLC5A1, and SLC5A8 expression is particularly concentrated in the region corresponding to cluster 1 (A), which is enriched by IL-17/TNF-α treatment.