Table 3.

Gene-based Association Analyses of 21 Noncoding Variants in Caveolin-1 with Apnea–Hypopnea Index Adjusting for Lung Function and Obstructive Sleep Apnea Physiological Endotypes

Covariates	Number of Variants	Burden Effect	Burden P Value	SKAT P Value	Sample Size
No covariate	21	−0.49	3.31 × 10−5	0.038	454
FEV1, predicted %	21	−0.49	2.92 × 10−5	0.032	454
FVC, predicted %	21	−0.47	6.34 × 10−5	0.041	454
No covariate	21	−0.40	0.012	0.054	350
T2D	21	−0.40	0.016	0.065	350
No covariate	19	−0.39	0.014	0.077	218
Collapsibility, % eupnea	19	−0.25	0.070	0.119	218
Compensation	19	−0.38	0.016	0.060	218
Loop gain	19	−0.33	0.020	0.083	218
Arousal threshold, % eupnea	19	−0.23	0.099	0.117	218

Definition of abbreviations: SKAT = sequence kernel association test; T2D = type 2 diabetes.