Skip to main content
. 2022 Aug 1;206(11):1317–1325. doi: 10.1164/rccm.202204-0671PP

Table 1.

Operational Descriptors and Threshold Values of the Diagnostic Criteria to Identify Persons (pre–Chronic Obstructive Pulmonary Disease [COPD]) at Higher Risk of Developing COPD and Those with Confirmed Disease (COPD)

  Diagnostic Criteria
Pre-COPD COPD
Spirometry post-bronchodilator FEV1/FVC ⩾ 0.7 FEV1/FVC < 0.7
  and and
Symptoms Chronic bronchitis (cough and phlegm daily for 3 mo over 3 yr) Chronic bronchitis, dyspnea, fatigue, comorbidities
  and/or and/or
Function DlCO < 80% predicted or FEV1 decline >40 ml/yr or PRISM Low DlCO, PAH, lung hyperinflation, hypoxia, hypercapnia
  and/or and/or
Structure Emphysema (>5% in CT-measured algorithms or diagnosed visually), vascular remodeling Emphysema, airways thickening, vascular remodeling

Definition of abbreviations: CT = computed tomography; DlCO = diffusing capacity for carbon monoxide; PAH = pulmonary arterial hypertension; PRISM = preserved ratio impaired spirometry.