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. 2022 Nov 29;13:969509. doi: 10.3389/fimmu.2022.969509

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Copyright © 2022 Li, Ma, Liao, Qi, Meng, Cai, Dai, Cao, Dong, Krämer, Yun, Hocher, Hong, Liu, Tang, He, Yin and Dai

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Proteomic Profiling of PBMC from SLE and RA patients and Health Volunteers. (A) The workflow of the study. All PBMC samples were used for 4D-LFQ proteomics analysis and ELISA analysis. (B, C) The distribution of numbers of quantified (B) peptides and (C) proteins in the 52 PBMC samples from three groups. Color dots represent multiple independent samples, SLE (n = 21), RA (n = 16), HC (n = 15). (D) The distribution of MS/MS spectral counts of quantified peptides. (E) The distribution of peptide numbers of quantified proteins. (F) The distribution of protein numbers in PBMC samples. (G) PCA of proteomic data in HC, SLE, and RA.