Skip to main content
. 2022 Nov 29;13:969509. doi: 10.3389/fimmu.2022.969509

Figure 2.

Figure 2

Differential analysis in protein expression levels between SLE and HC or RA. (A) The heatmap for the expression of PBMC proteins in SLE, RA, and HC. The expression of each proteins was normalized by Z score normalization. (B) Venn diagram summarising the differential and overlapping proteins between SLE and HC or RA (fold change(FC) > 1.5 or < 0.67, unpaired two-sided Student’s t-tests, P < 0.05). (C) Plots of fold changes of differentially expressed proteins in SLE vs. RA only, SLE vs. HC only, and SLE vs. both. (D) The enrichment score for 36 KEGG pathways by GSVA in SLE, RA, and HC. The brown and green nodes represent upregulation and downregualtion state of pathway, respectively (moderated t-test, P < 0.05). (E) The differentially activated KEGG pathways between SLE vs. RA and SLE vs. HC. The blue and purple bands represent the activated pathways of SLE vs. RA and SLE vs. HC, respectively; and the gray bands represent the unactivated pathway. (F) GSEA of complement and coagulation cascades gene sets were significantly differentially enriched between SLE and HC or RA (permutation test, P < 0.05).