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. 2022 Dec 13;17(12):e0278998. doi: 10.1371/journal.pone.0278998

Table 1. Characteristics of women in the LOUSSI study, stratified by smoking status (N = 199)a.

Nonsmokers (Cotinine < 0.5 ng/mL) Passive smokers (Cotinine 0.5–13.9 ng/mL) Active smokers (Cotinine≥14 ng/mL) P-value
N (%) (n = 71) N (%) (n = 70) N (%) (n = 58)
Age (years) 0.06
    21–25 6 (8.4) 10 (14.2) 15 (25.9)
    26–30 13 (18.3) 13 (18.6) 14 (24.1)
    31–35 23 (32.4) 27 (38.6) 12 (20.7)
    36–45 29 (40.9) 20 (28.6) 17 (29.3)
Race <0.001
    White 38 (53.5) 37 (53.6) 29 (50.0)
    Black 12 (16.9) 20 (29.0) 27 (46.6)
    Other 21 (29.6) 12 (17.4) 2 (3.4)
    Missing 1 (1.4)
Age at menarche(years) mean (SD) b 12.7 (2.0) 12.4 (1.7) 12.2 (1.5) 0.33
    Missing 2 (2.8) 4 (5.7) 1 (1.7)
Body Mass Index (kg/m 2 ) 0.03
    17.5–24.9 22 (31.4) 15 (21.8) 14 (24.1)
    25–29.9 26 (37.1) 19 (27.5) 12 (20.7)
    30–34.9 13 (18.6) 12 (17.4) 18 (31.1)
    ≥ 35 9 (12.9) 23 (33.3) 14 (24.1)
    Missing 1 (1.4) 1 (1.4)
Polycystic Ovary Syndrome 0.24
    No 47 (68.1) 38 (54.3) 36 (62.1)
    Yes 2 (31.9) 32 (45.7) 22 (37.9)
    Missing 2 (2.8)
Parity 0.11
    None 26 (36.6) 35 (51.5) 16 (28.1)
    One 17 (23.9) 14 (20.6) 17 (29.8)
    Two or more 28 (39.5) 19 (27.9) 24 (42.1)
    Missing 2 (2.9) 1 (1.7)
Marital Status <0.001
    Single 15 (21.7) 17 (26.6) 37 (67.3)
    Married 54 (78.3) 47 (73.4) 18 (32.7)
    Missing 2 (2.8) 6 (8.6) 3 (5.2)
Serum AMH categories (ng/mL) 0.32
    <1 19 (26.8) 19 (27.1) 9 (15.5)
    1–2 14 (19.7) 10 (14.3) 14 (24.1)
    2–3 20 (28.1) 18 (25.7) 22 (38.0)
    >3 18 (25.4) 23 (32.9) 13 (22.4)
Diminished ovarian reserve (DOR) (AMH<1 ng/mL) 0.23
    No 52 (73.2) 51 (72.9) 49 (84.5)
    Yes 19 (26.8) 19 (27.1) 9 (15.5)
NAT2 Acetylator Status
    Rapid/ Intermediate Acetylators 40 (61.5) 39 (61.9) 18 (62.1) 0.99
    Slow Acetylators 25 (38.5) 24 (38.1) 11 (37.9)
Missing 6 (8.5) 7 (10) 1 (3.3)

a Women with cotinine measurements.

b SD = Standard deviation