TABLE 1.
Borreliacidal assay results: killing titers of immune sera against B. burgdorferi B31 and B313
| Immune serum | 100% killing titer (reciprocal)a
|
||
|---|---|---|---|
| B313 (basal) | B313 (4th boost) | B31 (4th boost) | |
| Mouseb | |||
| Oms66-1 | <20 | 320 | <20 |
| Oms66-2 | <20 | 320 | <20 |
| Oms66-3 | <20 | 320 | <20 |
| Oms66-4 | <20 | 320 | <20 |
| Oms66-5 | <20 | 320 | <20 |
| Oms66-6 | <20 | 160 | <20 |
| Rabbit | |||
| nOms66 | <20 | 320 | <20 |
| Adsorbed nOms66 | <20 | 160c | <20 |
| hOms66 | <20 | <20 | <20 |
| Infection immune | <20 | 40 | 160 |
a
100% killing indicates that after incubating organisms with immune serum and complement for 6 h, no viable organisms remained.
b
Oms66-1 to -6 represent results for the six different mice that were immunized with nOms66 protein.
c
The titer for the adsorbed serum was calculated with the assumption that the starting serum was diluted 1:4 compared to the unadsorbed serum.