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. 2022 Oct 17;15(12):2899–2908. doi: 10.1111/cts.13417

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© 2022 The Authors. Clinical and Translational Science published by Wiley Periodicals LLC on behalf of American Society for Clinical Pharmacology and Therapeutics.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Evobrutinib population pharmacokinetic model structure. ALAG, absorption lag time; CL/F, apparent clearance; D ₁, duration of zero‐order input; F, oral bioavailability; k ₂₀, elimination rate constant; k ₂₃, transfer rate from central to peripheral compartment; k ₃₂, transfer rate from peripheral to central compartment; k _a, first‐order absorption rate constant; Q/F, apparent intercompartmental clearance; V2/F, apparent central volume of distribution; V3/F, apparent peripheral volume of distribution.