TABLE 3.
Parameter estimates of the final Bruton's tyrosine kinase receptor occupancy model for evobrutinib
| Parameter | Estimate | RSE % | 95% CI |
|---|---|---|---|
| k out (L/h) | 0.00437 | 7.7 | 0.004–0.005 |
| k irrev (ml/ng/h) | 0.0135 | 8.1 | 0.011–0.016 |
| Additive error | 0.00317 | 16.7 | 0.002–0.004 |
| Proportional error | 0.43 | 8.4 | 0.359–0.501 |
| Parameter | Estimate (RSE %) | Etabar (SE) | CV % | Shr % |
|---|---|---|---|---|
| BPV k out | 0.217 (45.3%) | −0.002 (0.067) | 49.2 | 6.9 |
| BPV k irrev | 0.103 (40.5%) | −0.007 (0.043) | 32.9 | 12.9 |
Abbreviations: BPV, between‐participant variability; CI, confidence interval; CV%, coefficient of variation (%), Etabar, arithmetic mean of the η estimates; K irrev, second‐order irreversible binding rate constant; k out, first‐order elimination rate of Bruton's tyrosine kinase protein; RSE, relative standard error; SE, standard error; Shr, shrinkage.