TABLE 4.

Simulated percentage of participants with minimum Bruton's tyrosine kinase receptor occupancy above the four thresholds of interest (70%, 80%, 90%, and 95%) over 24 h at steady‐state for different dose/regimen and food state combinations

BTKO threshold	Prandial state	25 mg	50 mg	75 mg	100 mg	200 mg
		Simulated % of participants
q.d. dosing regimen
0.70	Fasted	98	100	100	100	100
0.80		88	97	99	99	100
0.90		36	59	71	77	87
0.95		4	13	20	24	39
0.70	Fed	99	100	100	100	100
0.80		95	99	99	99	100
0.90		54	74	82	85	92
0.95		10	22	29	34	51
b.i.d. dosing regimen
0.70	Fasted	100	100	100	100	100
0.80		99	100	100	100	100
0.90		88	97	99	100	100
0.95		38	68	81	86	94
0.70	Fed	100	100	100	100	100
0.80		100	100	100	100	100
0.90		96	99	100	100	100
0.95		59	85	90	93	97

Abbreviations: b.i.d., twice‐daily; BTKO, Bruton's tyrosine kinase occupancy; q.d., once‐daily.