TABLE 4.

Simulated percentage of participants with predose BTKO above the four thresholds (70%, 80%, 90%, and 95%) over 24 h at steady‐state for different dose/regimen and food state combinations

BTKO threshold	Food state	Simulated % of participants
		10 mg	25 mg	35 mg	45 mg	50 mg	75 mg	100 mg	200 mg
q.d. dosing regimen
0.70	Fasted	93	99	100	100	100	100	100	100
0.80		79	95	97	98	98	99	99	100
0.90		43	70	77	81	83	88	90	94
0.95		12	31	39	46	48	55	60	72
0.70	Fed	97	100	100	100	100	100	100	100
0.80		89	97	98	99	99	100	100	100
0.90		57	79	85	87	88	92	93	96
0.95		20	43	51	55	57	64	70	79
b.i.d. dosing regimen
0.70	Fasted	99	100	100	100	100	100	100	100
0.80		96	100	100	100	100	100	100	100
0.90		78	94	97	98	99	99	100	100
0.95		45	72	81	85	87	92	94	96
0.70	Fed	100	100	100	100	100	100	100	100
0.80		98	100	100	100	100	100	100	100
0.90		88	97	99	99	99	100	100	100
0.95		60	84	89	93	93	95	96	98

Abbreviations: b.i.d., twice daily; BTKO, Bruton's tyrosine kinase occupancy; q.d., once daily.