FIGURE 2.

Visual predictive check (VPC; n = 1000) of (a) the final pharmacokinetic/pharmacodynamic (PK/PD) model of the psychedelic intensity produced by N,N‐dimethyltryptamine (DMT) versus time across all dose levels and (b) the final PK/PD model of the psychedelic intensity produced by DMT versus time stratified by dose after intravenous administration in 13 healthy subjects. Circles are observations, the solid line is the median of the observations, dashed lines are 5th and 95th percentiles of the observations, the red areas are the 95% confidence intervals of the median of the simulated data, and the blue areas are the 95% confidence intervals of the 5th and 95th percentiles of the simulated data. The dose stratified VPCs are presented with median predictions only, due to the low sample size of each panel. Doses are expressed as DMT fumarate.