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. 2022 Sep 27;15(12):2928–2937. doi: 10.1111/cts.13410

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© 2022 The Authors. Clinical and Translational Science published by Wiley Periodicals LLC on behalf of American Society for Clinical Pharmacology and Therapeutics.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.

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Schematic presentation of the final pharmacokinetic/pharmacodynamic model of N,N‐dimethyltryptamine (DMT), indole 3‐acetic acid (IAA), and the psychedelic intensity produced by DMT. CL, clearance for N,N‐dimethyltryptamine; Vc, central volume of distribution for N,N‐dimethyltryptamine; Q, intercompartmental clearance for N,N‐dimethyltryptamine; Vp, peripheral volume of distribution for N,N‐dimethyltryptamine; CL(m), apparent clearance for indole 3‐acetic acid; V(m), apparent volume of distribution for indole 3‐acetic acid; k _e0, the effect compartment equilibrium rate constant.