TABLE 1.
Final pharmacokinetic and pharmacodynamic parameter estimates
| Parameter | Estimate (95% CI) | %RSE |
|---|---|---|
| CL, L/min | 26.0 (20.6–33.6) | 15.1 |
| Q, L/min | 2.99 (1.87–5.44) | 36.6 |
| Vc, L | 221 (181–273) | 12.1 |
| Vp, L | 59.0 (48.0–82.7) | 18.5 |
| CL(m), L/min | 0.093 (0.076–0.11) | 10.6 |
| V(m), L | 9.55 (8.07–11.1) | 9.8 |
| BSV CL, CV% | 47.3 (37.5–65.3) | 41.0 |
| BSV V(m), CV% | 29.0 (21.7–41.5) | 45.0 |
| Residual error DMT, CV% | 50.0 (43.9–58.9) | 19.2 |
| Residual error IAA, CV% | 19.0 (16.8–21.8) | 16.3 |
| E max | 10 FIX | |
| EC50,e, nM | 94.7 (75.4–123) | 14.9 |
| k e0, min−1 | 1.38 (1.16–1.94) | 17.5 |
| γ | 2.87 (2.63–3.02) | 4.2 |
| BSV EC50,e, CV% | 38.6 (29.1–50.4) | 34.1 |
| BSV γ, CV% | 77.3 (58.1–103) | 36.6 |
| Residual error intensity ratings, SD | 0.82 (0.55–0.90) | 7.8 |
Abbreviations: BSV, between subject variability; CI, confidence interval; CL, clearance for N,N‐dimethyltryptamine; CL(m), clearance for indole 3‐acetic acid; CV%, coefficient of variation percentage; DMT, N,N‐dimethyltryptamine; EC50,e, the concentration in the effect compartment needed to achieve 50% of the maximum response; E max, maximum achieved psychedelic intensity; IAA, indole 3‐acetic acid; k e0, the effect compartment equilibrium rate constant; Q, intercompartmental clearance for N,N‐dimethyltryptamine; Vc, central volume of distribution for N,N‐dimethyltryptamine; V(m), volume of distribution for indole 3‐acetic acid; Vp, peripheral volume of distribution for N,N‐dimethyltryptamine; γ, Hill coefficient describing the steepness of the relationship.