FIGURE 5.

PK/PD in silico model predictions of serum TXB₂ during chronic aspirin treatment in patients with polycythemia vera (PV) with serum TXB₂ greater than 10 ng/ml on 100 and 40 mg q.d. The in silico predictions of aspirin PK/PD were performed for 3 representative days under long‐term 100 mg (blue line) and 40 mg (red line) q.d. aspirin regimens. The experimental PV data of serum TXB₂, expressed as percentage of the mean value of patients with PV are also shown: the red dot and error bar represents the mean serum TXB₂ (±SD) of 18 patients with PV with inadequate inhibition under 100 mg q.d., and the green dot represents serum TXB₂ values of 10 patients with PV with inadequate inhibition under 40 mg q.d. Black dots represent the overlaid TXB₂ measurements related to each patient. All serum TXB₂ values in the model are calculated and represented as percentage of the mean value of patients with PV off aspirin. ²³ PD, pharmacodynamics; PK, pharmacokinetics; TX, thromboxane