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. 2022 Dec 5;8(6):e200044. doi: 10.1212/NXG.0000000000200044

Figure 4. Pathologic Findings of a Patient With Heterozygous p.Q318H Mutation in HTRA1.

Figure 4

(A) Fresh hemorrhage seen in the hematoma (sword symbol). (B) Small arteries with marked intimal thickening, hyalinosis, and narrowing of the lumen. (C) Hyalinization of the vascular wall. (D) Loss of medial smooth muscle cells in small arteries (blue arrow symbol). (E) Small arteries with a wavy multilayered elastic lamina (black arrow symbol). (F) Small artery with intramural hematoma-like structure (star symbol). Hematoxylin-eosin stain (A and B). Masson stain (C). Immunohistochemical staining of α-smooth muscle actin antibody (D). Elastica-Goldner stain (E and F). The scale bar is in the bottom right corner of each figure. HTRA1 = high-temperature requirement A serine peptidase 1.