Figure 1. Decile of 25(OH)D PGS and Measured 25(OH)D Levels in 935 People With MS From the JHU Cohort.

25(OH)D PGS are derived from summary statistics in which the primary model was adjusted for BMI. The association between circulating 25(OH)D levels and 25(OH)D PGS are adjusted for also BMI among people with MS. We excluded individuals with measured levels exceeding 70 ng/mL, as previous studies suggest this threshold may be the physiologic limit of 25(OH)D derived from nonsupplemental sources. Similar results were obtained when applying a threshold of 100 ng/mL (not shown). 25[OH]D = 25-hydroxyvitamin D; PGS = polygenic score.