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. 2022 Nov 17;10(1):e200043. doi: 10.1212/NXI.0000000000200043

Figure 2. Determinants of Anti-S IgG Titers in Patients With MS Treated With Anti-CD20 Antibodies.

Figure 2

(A) Relation between baseline CD19+ B-cell count at t0 and temporal trends in anti-S IgG titers in anti-CD20–treated patients. (B) Relation between total CD19+ B-cell count at t0 and CD19+CD27+ memory B-cell count at t0 in anti-CD20–treated patients; (C) Effect of administration of anti-CD20 infusions after the 2nd vaccine dose on anti-S IgG titers; a blue circle indicates that the patient has in the meanwhile received an anti-CD20 infusion. Anti-S IgG titers and cell counts are shown on a logarithmic scale. Anti-S = antispike; IgG = immunoglobulin G.