Table 5. Multivariate analysis of factors associated with in-hospital mortality.

Variable	OR (95% CI)	p
Oseltamivir use within 48 h after ICU admission	1.88 (1.19-2.94)	0.006
Liver failure	13.60 (4.12-44.51)	< 0.001
Cardiac arrhythmias	3.16 (1.76-5.67)	< 0.001
Hand/foot ischemia	12.55 (2.41-65.57)	0.003
Hospital-acquired infection	3.60 (2.33-5.56)	< 0.001
Hemorrhage	3.97 (1.36-11.71)	0.012
Age	1.02 (1.00-1.03)	0.065
SOFA score at admission	1.30 (1.21-1.38)	< 0.001
Charlson Comorbidity Index	1.21 (1.09-1.35)	< 0.001

We included in the model all variables with a p value < 0.05 on Tables 1 to 3 in the univariate model, in the presence of collinearity, we selected the most clinically relevant variable (in bold): type of infection and admission type; frailty and age; SAPS 3, use of vasopressors, renal replacement therapy, ventilatory support, platelets, creatinine, bilirubin at admission and SOFA score at admission; diabetes, chronic heart disease, hypertension, chronic kidney disease, chronic hematologic disease, history of smoking and Charlson Comorbidity Index; obesity and BMI; immunosuppressive therapy and solid organ transplant. We excluded laboratory variables with missing data.