TABLE 1.
Randomized Controlled Trials in Critically Ill Children From the Pediatric Acute Lung Injury and Sepsis Investigator’s Network
| Year (Reference no.) | Countries | Study Interventions (Study Name) | Patients (Sites) | Funding |
|---|---|---|---|---|
| 2002 (4) | United States | Comparison of three mechanical ventilation weaning methods: pressure support, volume support, and usual care | 182 (10) | Foundation and Industrya |
| 2005 (5) | United States | Endotracheal calfactant versus placebo for acute lung injury | 153 (21) | Industry |
| 2005 (6) | United States | Prone positioning for pediatric acute lung injury | 102 (7) | NIH |
| 2007 (7) | United States, Canada, and UK Belgium | Noninferiority trial of transfusion hemoglobin threshold of 7 versus 9.5 mg/dL (Transfusion Requirements in the Pediatric Intensive Care Unit Study) | 637 (19) | CIHR |
| 2012 (11) | United States, Chile | Lucinactant for acute hypoxemic respiratory failure in children < 2 years of age | 165 (36) | Industry |
| 2013 (13) | United States, Canada, Israel Australia, New Zealand, South Korea | Endotracheal calfactant versus placebo for acute lung injury | 110 (24) | Industry |
| 2015 (8) | United States | Cluster randomized trial of sedation protocols in children with acute respiratory failure | 2449 (31) | NIH |
| 2017 (12) | United States | Targets for managing critical illness-related hyperglycemia: glucose 80–110 vs 140–180 mg/dL (Heart and Lung Failure-Pediatric INsulin Titration Trial) | 713 (35) | NIH and Industrya |
| 2018 (10) | United States | Calfactant for acute lung injury in pediatric stem cell and oncology patients | 43 (17) | U. S. Food and Drug Administration and Industrya |
| 2019 (9) | United States, Canada, France | Comparison of fresh versus standard issue packed red blood cells on multiple organ dysfunction syndrome (Age of Blood in Children in Pediatric Intensive Care Units study) | 1538 (50) | CIHR, NIH, and Programme Hospitalier Recherche Clinique (France) |
| 2019 (14) | United States | Continuous vs bolus gastric feeds in mechanically ventilated children in the PICU | 158 (7) | Foundation |
| 2021 (15) | United States | Central venous catheter-related early thrombosis with enoxaparin in critically ill children | 51 (7) | NIH |
CIHR = Canadian Institutes of Health Research, NIH = National Institutes of Health.
a
Industry provided devices and/or therapeutics but did not fund patient enrollment.