Table 3. Univariable and Multivariable Fine and Gray Regression Analysis for Factors associated with Liver-Related Death or Transplantation in Patients with Compensated Advanced Chronic Liver Disease.
| Variables | Univariable Analysis | Baseline Multivariable Model | Follow-Up Multivariable Model | |||
|---|---|---|---|---|---|---|
| Sub-Distribution HR (95% CI) | P | Sub-Distribution HR (95% CI) | P | Sub-Distribution HR (95% CI) | P | |
| Age (10-year increment) | 1.30 (0.77–2.22) | 0.325 | ||||
| Male (compared with female) | 1.65 (0.74–3.65) | 0.219 | ||||
| Platelet (10 x 109/L increment) | 1.00 (0.91–1.10) | 0.964 | ||||
| Albumin, g/dL | 0.39 (0.16–0.93) | 0.034 | 0.74 (0.21–2.70) | 0.653 | 0.88 (0.26–2.91) | 0.829 |
| MELD | 1.15 (1.02–1.30) | 0.025 | 1.00 (0.83–1.21) | 0.991 | 1.05 (0.87–1.26) | 0.609 |
| LS, kPa | 1.02 (1.00–1.04) | 0.057 | 1.03 (1.00–1.05) | 0.029 | 1.01 (0.99–1.04) | 0.271 |
| Baseline LS-SIR | 0.80 (0.69–0.91) | 0.001 | 0.85 (0.69–1.05) | 0.121 | 0.83 (0.66–1.04) | 0.097 |
| Baseline LS-VR | 0.84 (0.61–1.16) | 0.295 | 0.88 (0.58–1.32) | 0.535 | 0.95 (0.61–1.48) | 0.810 |
| ΔLS-SIR (10% increment) | 0.80 (0.48–1.32) | 0.377 | 0.72 (0.43–1.21) | 0.214 | ||
| ΔLS-VR (10% increment) | 0.41 (0.21–0.83) | 0.013 | 0.46 (0.23–0.91) | 0.026 | ||
Unless otherwise indicated, sub-distribution HRs are presented per one-unit increment of variable value. CI = confidence interval, HR = hazard ratio, LS = liver stiffness, LS-SIR = liver-to-spleen signal intensity ratio, ΔLS-SIR = changes in the LS-SIR in the 1-year follow-up MRI compared with that of the baseline MRI, LS-VR = liver-to-spleen volume ratio, ΔLS-VR = changes in LS-VR in the 1-year follow-up MRI compared with that in the baseline MRI, MELD = model for end-stage liver disease