Table 2. Cutoff Values of PDFF for Hepatic Steatosis (Histologic Fat Fraction ≥ 5%) and Their Corresponding Diagnostic Performance in the Development Set and Validation Set.
| Indices | Cutoffs (%) | Development Set | Sensitivity | ||||||
|---|---|---|---|---|---|---|---|---|---|
| Sensitivity | Specificity | PPV | NPV | Sensitivity | Specificity | PPV | NPV | ||
| CS-MRI-PDFF | 2.3* | 91.5 (172/188) | 68.9 (213/309) | 64.2 (172/268) | 93.0 (213/229) | 92.4 (157/170) | 63.0 (160/254) | 62.6 (157/251) | 92.5 (160/173) |
| 3.5† | 78.7 (148/188) | 91.3 (282/309) | 84.6 (148/175) | 87.6 (282/322) | 73.5 (125/170) | 88.6 (225/254) | 81.2 (125/154) | 83.3 (225/270) | |
| HISTO-MRS-PDFF | 2.6* | 91.0 (171/188) | 68.6 (212/309) | 63.8 (171/268) | 92.6 (212/229) | 88.8 (151/170) | 70.1 (178/254) | 66.5 (151/227) | 90.4 (178/197) |
| 4.0† | 73.9 (139/188) | 90.3 (279/309) | 82.25 (139/169) | 85.1 (279/328) | 74.7 (127/170) | 90.6 (230/254) | 84.1 (127/151) | 84.3 (230/273) | |
Results are presented as percentages (number of patients/total number of patients assessed). *Cutoff for 90% sensitivity, †Cutoff for 90% specificity. CS-MRI-PDFF = chemical-shift-imaging-based MRI-proton density fat fraction, HISTO-MRS-PDFF = high-speed T2-corrected multi-echo MR spectroscopy proton density fat fraction, NPV = negative predictive value, PPV = positive predictive value