Table 2.

Summary of results of simulations indicating probabilities for arriving at platform conclusions (effectiveness or futility) in each domain with varying sample sizes and effect sizes. The probabilities for arriving at platform conclusions can be conceptualised as similar to the power of the study

	Antiviral domain		Anticoagulation domain		Antibody domain
Treatment arms	2		3		2
Estimated sample size	2000		3200		1600
Odds ratio (effect)	Effective	Futile	Effective	Futile	Effective	Futile
1.10 (harmful)	0.01	0.89	0.00	0.80	0.01	0.83
1.00 (null)	0.03	0.67	0.03	0.53	0.03	0.58
0.80 (weak)	0.37	0.10	0.50	0.07	0.30	0.10
0.67 (moderate)	0.84	0.01	0.93	0.01	0.75	0.01
0.50 (strong)	1.00	0.00	1.00	0.00	0.99	0.00