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. 2022 Oct 31;23(12):1777–1787. doi: 10.1038/s41590-022-01329-5

Extended Data Fig. 6. Upstream signaling molecules and transcription factors demarcate the pre-vaccination endotypes.

Extended Data Fig. 6

(a) Scatter plot showing the discriminative power of NFκB- and Interferon-target genes for each of the vaccine in the ‘Immune Signatures Data Resource’. LogFC of the SLEA z-score of the two genesets between high vaccine responders and low vaccine responders is shown. (b) Overlap between the genes differentially expressed between the inflam.hi and inflam.lo endotypes and inflammatory signatures described in the literature. The significance of the overlap between ranked lists of genes was assessed by permutation. * indicate statistically significant overlap (permutation test: p ≤ 0.05) between the differentially expressed genes between the inflam.hi and inflam.lo endotypes and previously described inflammatory signatures extracted from the literature.