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. 2022 Oct 31;23(12):1777–1787. doi: 10.1038/s41590-022-01329-5

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — a–c, Line plots showing the expression of inflammatory pathways (a), ISGs (b) and B cells (c) as a function of time, separated by participants with low, middle or high pre-vaccination inflammation (inflam.lo, n = 235; inflam.mid, n = 237; inflam.hi, n = 304). Each colored line corresponds to one participant. LOESS regression was used to determine the average expression per pre-vaccination endotype (black lines). d, T_H2 cell markers fold change values over pre-vaccination data for several time points after vaccination (day 1, inflam.lo n = 117, inflam.mid n = 117, inflam.hi n = 139; day 3, inflam.lo n = 166, inflam.mid n = 165, inflam.hi n = 202; day 7, inflam.lo n = 159, inflam.mid n = 147, inflam.hi n = 198; day 14 inflam.lo n = 81, inflam.mid n = 103, inflam.hi n = 100). For each box plot, the vertical line indicates the median, the box indicates the interquartile range, and the whiskers indicate 1.5 times the interquartile range. Wilcoxon rank-sum test; *P < 0.05, **P < 0.01 and ***P < 0.001.