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. 2022 Oct 31;23(12):1777–1787. doi: 10.1038/s41590-022-01329-5

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 3 — (a) Principal variance analysis with the inflammatory states. Canonical inflammatory genes (b), interferon-stimulated genes (c), and B cell markers (d) expression over time in the three inflammatory states. (e) Log2 fold-change over pre-vaccination levels of B cell markers. For each boxplot, the vertical line indicates the median, the box indicates the interquartile range, and the whiskers indicate 1.5 times the interquartile range. Wilcoxon rank-sum test between two endotypes: p-values less than 0.05 are flagged with one star (*), p-values less than 0.01 are flagged with 2 stars (**), and p-values less than 0.001 are flagged with three stars (***). (f) Th2 cell markers over time.